• Dru as Manny
  • Gru as Sid
  • Oscar The Grouch (from Sesame Street) as Diego
  • Marlin (from Finding Nemo) as Scrat
  • Ted's Mom (from The Lorax) as Ellie
  • Margo as Peaches
  • Rafael (from Rio) as Ethan
  • Lucy Wilde as Granny
  • Eduardo as Captain Gutt
  • Vector as Soto
  • Dr. Nefario as Buck
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