• Jimmy Neutron as Mike
  • Tommy Pickles (from Rugrats) as Young Mike
  • Hugh Neutron as Derek Knight
  • Butch Pakovski as Johnny Worthington
  • Carl Wheezer as Sulley
  • Chief Wiggum (from The Simpsons) as Brock Pearson
  • Libby Folfax as Claire Wheeler
  • Eustace Strych as Randall
  • Sheen Estevez as Art
  • Coach Gruber as Yeti
  • Reptar (from Rugrats) and Ultra Lord as Terri Perry and Terry Perry
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